Covid cure with pine needle tea (suramin) / Hoito koronaan männynneulasteellä (suramiini)

Suramin is a synthetic molecule derived from toluene extracted from pine oil.
Suramiini on synteettinen molekyyli joka on johdettu tolueenista joka on eristetty mäntyöljystä.

PINE NEEDLE TEA/MÄNNYNNEULASTEE:
Wiki: https://en.wikipedia.org/wiki/Pine_needle_tea
Videos: https://www.youtube.com/results?search_query=Pine+Needle+Tea
Google search: https://www.google.com/search?q=pine+needle+tea
Google-haku: https://www.google.com/search?q=männynneulastee

>Suramin inhibits SARS-CoV-2 infection in cell culture by interfering with early steps of the replication cycle
https://www.immunology.ox.ac.uk/covid-19/covid-19-immunology-literature-reviews/suramin-inhibits-sars-cov-2-infection-in-cell-culture-by-interfering-with-early-steps-of-the-replication-cycle

>The enzyme, Guanine 7 Methyltransferase is responsible for the capping of the SARS-CoV-2 mRNA to conceal it from the host’s cellular defense.
https://chemrxiv.org/engage/chemrxiv/article-details/60c74e3e4c8919a35fad39a8

>the most potent inhibitor was a suramin analogue
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202001036

>With 9-day exposure, there was no effect with suramin concentrations of 100 microM or less. At 200 microM, 17% of the myelinated fibers were degenerating at 4 days and 53.3% by 9 days. At 300 microM, 72.7% of the myelinated fibers and at 1316 microM, 88.7% of the myelinated fibers were degenerating at 4 days.
https://pubmed.ncbi.nlm.nih.gov/7649218

Here we report that suramin, a 100-year-old drug, is a potent inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and acts by blocking the binding of RNA to the enzyme. In biochemical assays, suramin and its derivatives are at least 20-fold more potent than remdesivir, the currently approved nucleotide drug for treatment of COVID-19.
https://pubmed.ncbi.nlm.nih.gov/33674802/

Safety/Turvallisuus(suramiini ei ole myrkyllistä eikä kerry aivoihin):

>As suramin is a charged molecule and does not cross the blood brain barrier it exerts neurotoxic effects in the peripheral nervous system
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017835/

Spike protein/Piikkiproteiini:
https://www.researchgate.net/publication/343963794_Prunella_vulgaris_extract_and_suramin_block_SARS-coronavirus_2_virus_Spike_protein_D614_and_G614_variants_mediated_receptor_association_and_virus_entry_in_cell_culture_system
https://www.mdpi.com/1999-4915/13/5/873/htm
https://greatreject.org/pine-needles-a-super-drug-against-the-harmful-spike-proteins-of-the-covid-jab/

100 years of suramin: https://pubmed.ncbi.nlm.nih.gov/31844000/

Covid/Korona:
• Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
• Suramin inhibits SARS-CoV-2 infection in cell culture by interfering with early steps of the replication cycle

Anti-oxidant/Andioksidantti:
• Antioxidant activity and analysis of proanthocyanidins from pine (Pinus densiflora) needles
• Antioxidant Potential of Pine Needles: A Systematic Study on the Essential Oils and Extracts of 46 Species of the Genus Pinus
• Antioxidant and antiapoptotic effects of pine needle powder ingestion and endurance training in high cholesterol-fed rats
• Antioxidant principles from the needles of red pine, Pinus densi flora
• Effect of extracts from pine needle against oxidative DNA damage and apoptosis induced by hydroxyl radical via antioxidant activity
• Antioxidant, Antimutagenic, and Antitumor Effects of Pine Needles ( Pinus densiflora )
• Antioxidant Potential of Pine Needles: A Systematic Study on the Essential Oils and Extracts of 46 Species of the Genus Pinus
• Antioxidant activity and analysis of proanthocyanidins from pine (Pinus densiflora) needles
• Effect of extracts from pine needle against oxidative DNA damage and apoptosis induced by hydroxyl radical via antioxidant activity

Anti-microbial/Mikrobilääke:
• A Novel Antimicrobial Peptides From Pine Needles of Pinus densiflora Sieb. et Zucc. Against Foodborne Bacteria
• Antibacterial activity of water-soluble extract from pine needles of Cedrus deodara
• Volatile components and antibacterial effects of pine needle (Pinus densiflora S. and Z.) extracts
• Antibacterial activity of organic acids in aqueous extracts from pine needles (Pinus massoniana Lamb.)
• Antibacterial activity of water-soluble extract from pine needles of Cedrus deodara
• Antimicrobial effectiveness of pine needle extract on foodborne illness bacteria

Anti-viral/Viruksia torjuva:

• Suramin Antiviral Therapy in the Acquired Immunodeficiency Syndrome
• Anti-viral activity of suramin against influenza A virus in A549 cells
• Suramin inhibitsin vitro infection by duck hepatitis B virus, rous sarcoma virus, and hepatitis delta virus
• Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors
• Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
• Delivery of Suramin as an Antiviral Agent through Liposomal Systems
• Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection

Anti-hypertension/Verenpainetta alentava:

• Bioactivity-Guided Fractionation of Pine Needle Reveals Catechin as an Anti-hypertension Agent via Inhibiting Angiotensin-Converting Enzyme
• Characterization of Vasorelaxant Principles from the Needles of Pinus morrisonicola Hayata

Anti-inflammatory/Tulehdusta lieventävä:

• Phytochemical composition, anti-inflammatory activity and cytotoxic effects of essential oils from three Pinus spp
• Bioactivity-Guided Fractionation of Pine Needle Reveals Catechin as an Anti-hypertension Agent via Inhibiting Angiotensin-Converting Enzyme
• Protective effect of pine (Pinus morrisonicola Hay.) needle on LDL oxidation and its anti-inflammatory action by modulation of iNOS and COX-2 expression in LPS-stimulated RAW 264.7 macrophages
• Anti-Inflammatory Principles from the Needles of Pinus taiwanensis Hayata and In Silico Studies of Their Potential Anti-Aging Effects
• Anti-inflammatory properties of fermented pine (Pinus morrisonicola Hay.) needle on lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells

Cancer/Syöpä:

• Antioxidant, antimutagenic, and antitumor effects of pine needles (Pinus densiflora)
• Anti-oxidant activity and effect of Pinus morrisonicola Hay. on the survival of leukemia cell line U937
• Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression
• Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest
• Inhibitory effects of α-pinene on hepatoma carcinoma cell proliferation
• A pilot study of suramin in the treatment of progressive refractory follicular lymphomas"

HIV/AIDS:

• Suramin in the treatment of AIDS: mechanism of action
• 1984—Discovery of the First Anti-HIV Drug, Suramin
• The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1
• Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells.

Autism/Autismi:

• Suramin and Autism
• Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

Safety/Turvallisuus:
• As suramin is a charged molecule and does not cross the blood brain barrier it exerts neurotoxic effects in the peripheral nervous system

Youtube videos: https://www.youtube.com/results?search_query=suramin

Suramin is on the World Health Organization's List of Essential Medicines.

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